Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DMEN890) | |||||
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| DME Name | mevalonate diphosphate decarboxylase (MDD), Homo sapiens (human) | ||||
| Gene Name | MDD | ||||
| UniProt ID | |||||
| EC Number | EC: 4.1.1.33 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (human) (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta. . | ||||
| Sequence |
MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF
TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPT AAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKD SIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEM ARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKV AYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAM EPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA |
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| Structure | |||||
| Function | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. | ||||
| Full List of Metabolic Reactions (MR) Catalyzed by This DME | ||||||||||||||||||||||||||||
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| References | |||||
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| 1 | Study of the metabolism of flucytosine in Aspergillus species by 19F nuclear magnetic resonance spectroscopy | ||||
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