Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1065)
DME Name Nitroreductase (NTR), Trichomonas vaginalis
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; TVAG_026310
Gene Name NTR
UniProt ID
A2DZ34_TRIVA
Gene ID
4772298
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Trichomonas vaginalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metamonada
Phylum: Parabasalia
Class: Trichomonadida
Order: Trichomonadida
Family: Trichomonadidae
Genus: Trichomonas
Species: Trichomonas vaginalis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human vagina.
Sequence
MTSVFECIERRRTIRHYDQNWVCPKEHLEAIVNAALKSPTACNRQSIDLLVITNKEVLDK
IGEVGLNTLKKGTKEHMEERKHEGYKNVFTCDAPVLFLLVKNDRVNPLYTDVDAGIMCES
IMLTAASYGYGTMCIGVLRATDLYEAVGIHKEDLAMAVCMGKIEDGYVPPEKPIKCKATY
IE
Function This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
References
1 Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64.

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