Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1137)
DME Name Maltose phosphorylase (malP), Lactobacillus acidophilus
Synonyms Glycoside hydrolase 65 protein; Glycoside hydrolase family 65; Glycoside hydrolase family 65 protein; Kojibiose phosphorylase; LBA1870
Gene Name malP
UniProt ID
Q5FI04_LACAC
Gene ID
3251782
EC Number    EC: 2.4.1.8     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.8
Lineage    Species: Lactobacillus acidophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKRIFEIDPWKVITHKFDPKDKRLQESMTAIGNDYMGMRGNFEEGYSGDSLQGTYLAGVW
FPDKTVVGWWKNGYPKYFGKTPNAPSFIGIGINVNGEKVDLAKVKFSDFELSLDMHQGLL
SRSFIYEGKDVKVKLEFERFLHIVQKEAALIKVKATVLEGHAKIDFDSTLDGTVVNEDSN
YGDRFWIPLGEDKDEKTIQVKTKKNPYDVPQFTVLLKEALRNNGVAVNGEVTTEDAKLSE
RFSVELDEGQSYELEKDVIVVTSRDVEEKDQAAVANNLMSKLQTKSFEDNLADHTEAWKK
RWETSDVEISGDDAAQQGIRFNICQLFMTYYGEDKRLNVGPKGFTGEKYGGATYWDTEAF
IVPMYLAVTKPSVTRALLQYRHDQLPGAYHNAKEQGLPGALFPMVTFNGIECHNEWEITF
EEIHRNADIPHAIAMYTDYTGDDSYVKNEGMDVLVGTARFWAARVHWSKMRNKYVMHGVT
GPNEYENNVNNNWFTNTMARWLLKYTLERLPLATKEAQERVRVTDEEKAKWQDIVDNMYL
PEDEDLGIFLQQDDFLDKDIRPVTEIEDQRPINQHWSWDKILRSPFIKQADVLQGIYFFD
DQYTMDQKEKNFDFYEPLTVHESSLSPCIYSIMAAELGKKEKAVELYQRTARLDLDNYNN
DTVDGLHITSMSGSWLAIVQGFAGMRYDHDQLKFNPFVPDGWDHYSFKINYRGRLIEVYV
DHDECKITLLSGDDLEVMVHDNKLDLKEGKTKCLKA
Pathway Metabolic pathways (lac01100 )
Starch and sucrose metabolism (lac00500 )
Function This enzyme catalyzes the conversion of maltose to D-glucose and beta-D-glucose 1-phosphate.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
M-7403
 Drug Info Phase 1/2 Prostate cancer ICD11: 2C82 [1]
References
1 Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010 Oct;23(10):781-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.