Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1141)
DME Name Aminoglycoside acetyltransferase (aac), Providencia stuartii
Synonyms Aminoglycoside 2'-N-acetyltransferase; AAC(2')-Ia; aac
Gene Name aac
UniProt ID
AAC2_PROST
Gene ID
31518288
EC Number    EC: 2.3.1.59     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.59
Lineage    Species: Providencia stuartii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Providencia
Species: Providencia stuartii
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVA
IIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQ
KLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW
Structure
5US1
Function This enzyme catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Plazomicin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Dibekacin
 Drug Info Phase 4 Acute lower respiratory infection ICD11: CA4Z [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000282 Arbekacin 2'-N-acetyl ABK Conjugation - N-Acetylation Arbekacin [2]
MR004596 Dibekacin 2'-N-acetyl DKB Unclear - Unclear Dibekacin [2]
References
1 Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.
2 Enzymatic 2'-N-acetylation of arbekacin and antibiotic activity of its product J Antibiot (Tokyo). 1996 May;49(5):458-64. doi: 10.7164/antibiotics.49.458.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.