Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1225)
DME Name Beta-lactamase (blaB), Fusobacterium varium
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Sel1 repeat protein; FVAG_01242
Gene Name blaB
UniProt ID
C6JIU1_FUSVA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Fusobacterium varium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium varium
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKGKNKINVIIYVIILLFSLGNLVFAEDSTEEQVKQGNSYYENGKYDLAEKYWKMAADKG
NVDALYALGILYEDADKLDLAEAYYKLAADKGDADAQYNLGVLYDDQKKYDLAEAYYKKA
AAQGDVDAQYNLGCLYDTQKNFTEAEKYYKLAADQGDKGAQYNLGCLYDTQKKFALAEQF
YRLAANQGDIDAQYNIGILYKNQKKFVLAEKYWKMAADQGDLEAQNNLGILYEEQKKYDL
AEIYYKKAADGGLKDAQYNLGLFYSDRGKKDLSKKYSELAENNK
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [2]
Ticarcillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
References
1 Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
2 Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9.

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