Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1227)
DME Name Beta-lactamase (blaB), Neisseria sicca
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; HMPREF3277_11020
Gene Name HMPREF3277_11020
UniProt ID
A0A1S1G219_9NEIS
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Neisseria sicca     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria sicca
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MKPAQTSLLFALLLGLLPAAYAEDYDDEAYQNLITQCTRNQLDSCVTLGIWTRDYLESPA
DAYLPLKKACDGKNMKGCNVLANLYLDPYSGLGMDYSKALELYRKACKGGYDNACRNAKE
TEQEMRSQTAEDRAVKRQERLEALQRSCMGENDAACRALQRELQR
Function This enzyme hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [2]
References
1 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
2 Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.

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