Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1260)
DME Name Unclear metabolic mechanism (DME-unclear), Clostridium perfringens
Gene Name DME-unclear
Lineage    Species: Clostridium perfringens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium perfringens
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Quercetin
 Drug Info Phase 4 Hypertriglyceridaemia ICD11: 5C80 [3]
References
1 Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
2 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
3 In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites. Food Nutr Res. 2014 Apr 15;58.

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