Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1354)
DME Name Beta-lactamase (blaB), Prevotella loescheii
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; HMPREF1991_01269
Gene Name blaB
UniProt ID
A0A069QS91_PRELO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Prevotella loescheii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella loescheii
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MFRILFSALCAFALNASANNIPTASPEEVGMSLARLRAADEVILRAIRDHRTPGAVLAVV
RHGKMAYLKAYGNRQTYPTTQPMTTQTVFDMASCTKPMATAISAMLLVERGKLRLSDPVS
TYLPEFKNWHGEGKDSVTIRVEDLLTHTSGLPPYAPVKTLAEANGKPNPAKLMAYIARCK
RDFKPHTDMQYSCLNYITLQNIVERITGQSLRTFAANNIFIPLGMNHTDFLPCAPDKSGK
LANTSQPRWVTNGEQASLTPIAPTERQPNGTVKLGQVHDPLACTLNGGVSGNAGLFSSAE
DVATLCAMLQNGGEWGGKRILSPLTVKAMRSIPQNFNSFGRSLGWDVSSAYASNQGDLLS
DEAYGHTGYTGTSIVIDPVNDLSIILLCNSVHPVDTTNVIRLRAQVANAVAASITNEAAA
FPGYYYVRMRTFEAEPPIRSTDIVMLGNSLTEGGRDWAEKLGKPNVRNRGISGDVAMGID
ARLFQITPHKPAKIFLLVGINDVSHDLTVDSIVTNIRLLVEHIHAQSPKTKLVLQSLLPI
RESTGRWKRLQGKTDMIPQINARLEALAREKGLTFINLFPHFTEPGTNVLRSELTYDGLH
LSKAGYDVWVKLLKPHL
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.

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