Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1553)
DME Name Tyrosine decarboxylase (tdc), Lactobacillus brevis
Synonyms Levodopa decarboxylase; L-dopa decarboxylase; L-tyrosine decarboxylase; TDC; tdc; tdcA; CNR29_12740; N624_0219; TDC; UCCLBBS449_2369
Gene Name tdc
UniProt ID
TYRDC_LACBR
Gene ID
4413406
EC Number    EC: 4.1.1.25     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.25
Lineage    Species: Lactobacillus brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MEKSNRSLKDLDLNALFIGDKAENGQLYKDLLNKLVDEHLGWRKNYIPSDPNMIGPEDQN
SPAFKKTVGHMKTVLDQLSERIRTESVPWHSAGRYWGHMNSETLMPALLAYNYAMLWNGN
NVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFAMK
EVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQTK
HYSWMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVGVAGSTEE
GAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQKVHAENH
VFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDTISYFATY
VFEKGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIEGAHRYYDF
LKNLKFEVAGKRISVHPLISPDFNMVDYVLKEDGNDDLIEMNRLNHAFYEQASYVKGSLY
GKEYIVSHTDFAIPDYGDSPLAFVESLGFSEVEWRHAGKVTIIRASVMTPYMNQRENFDY
FAPRIKKAIQADLEKVYASVNQKENV
Structure
5HSI ; 5HSJ
Function This enzyme catalyzes the decarboxylation of L-tyrosine to produce tyramine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Levodopa
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
L-tyrosine
 Drug Info Investigative Phenylketonuria ICD11: 5C50 [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
L-tyrosine
 Drug Info Investigative Phenylketonuria Km = 590 microM [2]
References
1 Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310.
2 Tyrosine decarboxylase from Lactobacillus brevis: soluble expression and characterization. Protein Expr Purif. 2014 Feb;94:33-9.

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