Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1586)
DME Name Oxygen-insensitive NADPH nitroreductase A (nfsA), Pseudomonas putida
Synonyms Oxygen-insensitive NAD(P)H nitroreductase A; Modulator of drug activity A; nfsA; pnrA
Gene Name pnrA
UniProt ID
Q7B4Y3_PSEPU
EC Number    EC: 1.5.1.38     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.38
Lineage    Species: Pseudomonas putida     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas putida
Subspecies: Pseudomonas putida JLR11
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MSLQDEALKAWQARYGEPANLPAADTVIAQMLQHRSVRAYSDLPVDEQMLSWAIAAAQSA
STSSNLQAWSVLAVRDRERLARLARLSGNQRHVEQAPLFLVWLVDWSRLRRLARTLQAPT
AGIDYLESYTVGVVDAALAAQNAALAFEAQGLGIVYIGGMRNHPEAMSEELGLPNDTFAV
FGMCVGHPDPAQPAEIKPRLAQSVVLHRERYEATEAEAVSVAAYDRRMSDFQHRQQRENR
SWSSQAVERVKGADSLSGRHRLRDALNTLGFGLR
Function This enzyme can catalyze FMN and also can catalyze FAD and riboflavin with lower activity.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrobenzoate
 Drug Info Investigative Discovery agent ICD: N.A. [1], [2]
References
1 PnrA, a new nitroreductase-family enzyme in the TNT-degrading strain Pseudomonas putida JLR11. Environ Microbiol. 2005 Aug;7(8):1211-9.
2 A Lethal Case of Pseudomonas putida Bacteremia Due to Soft Tissue Infection. Infect Dis Clin Pract (Baltim Md). 2013 May;21(3):147-213.

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