Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1725)
DME Name Beta-galactosidase (bgaB), Enterobacter cloacae
Synonyms Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; Lactase; lacZ
Gene Name lacZ
UniProt ID
BGAL1_ENTCL
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSDTPSLTLSALLARRDWENPVVTQWNRLAAHAPLHSWRNEPSARDDAGSARRQTLNGLW
RFSYFTAPEQVPQAWVTEDCADAVAMPVPSNWQMQGFDTPIYTNVTYPIPVNPPFVPQEN
PTGCYSLTFEVDDAWLQSGQTRIIFDGVNSAFHLWCNGQWIGYSQDSRLPAEFDLSAALR
PGQNRLAVMVLRWCDGSYLEDQDMWRMSGIFRDVTLLHKPETQIADYHVVTDLNAELDRA
VLKVDVTLAGAGFADGEVVFTLWRKGEKCASVSRQPGSAIVDERGSWAERLTVTIPVETP
ALWSAETPELYRLTMALLNPQGEVLEIEACDVGFRRVEISNGLLKLNGKPLLIRGVNRHE
HHSENGQVMDEATMRRDIETMKQHSFNAVRCSHYPNHPLWYQLCDRYGLYVVDEANIETH
GMVPMSRLADDPRWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWLKTT
DPTRPVQYEGGGANTAATDIVCPMYARVDRDQPFPAVPKWSIKKWIGMPDETRPLILCEY
AHAMGNSFGGFAKYWQAFRSHPRLQGGFVWDWVDQALTKRDEDGNTFWAYGGDFGDKPND
RQFCLNGLVFPDRTPHPALYEAHGPQQFFTFTRVSTSPLVIEVQSGYLFRHTDNEVLNWT
VARDGDVLVAGEVTLAMVPEGTQRLEIALPELNAGPGEVWLNVEVRQPRATPWSPAAIAA
AGSSGRFRLRSLLLRQPRRRAAVLTQTDRILEIAHRQQRWQFDRASGNLTQWWRNGVETL
LSPLTDNVSRAPLDNDIGVSEATKIDPNAWVERWKAAGMYDLTPRVLHCEAEQHAGEVVV
TTQHVLEYRGKALFLSRKVWRIDEQGVLHGDIQVDMASDIPEPARIGLSVHLAETPENVR
WLGLGPHENYPDRKLAAQQGRWTLPLEAMHTPYIFPTENGLRCDTRELVVGMHQLNGHFH
FSVSRYSQQQLRETTHHHLLREEPGCWLNLDAFHMGVGGDDSWSPSVSPEFILQTRQLRY
TFSWQQNP
Function This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [1]
References
1 In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.

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