Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1798)
DME Name Beta-glucuronidase (uidA), Acidobacterium capsulatum
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ACP_2665; GUS
Gene Name uidA
UniProt ID
C1F2K5_ACIC5
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Acidobacterium capsulatum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Acidobacteria
Class: Acidobacteriia
Order: Acidobacteriales
Family: Acidobacteriaceae
Genus: Acidobacterium
Species: Acidobacterium capsulatum
Subspecies: Acidobacterium capsulatum NBRC 15755
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAFARGGLAQTASQTTSSPVRVGLSVDASALGHTIPPDYTGLSYEQAQMANPNYFSGANT
QLAGFLRTLGRQGVLRIGGNTSEYTFWNRHAKPTAADEHLAAGPDKGHHAAAREVITPEA
VNNLSEFLDKTGWKLIYGLNLGKGTPENAADEAAYVMETIGADRLLAFQLGNEPDLFYRN
GIRPASYDFAAYAGDWQRFFTAIRKRVPNAPFAGPDTAYNTKWLVPFADKFKHDVKFISS
HYYAEGPPTDPSMTIERLMKPNPRLLGETAGLKQVEADTGLPFRLTETNSCYQGGKQGVS
DTFAAALWAGDLMYQQAAAGSTGINFHGGGYGWYTPVAGTPEDGFIARPEYYGMLLFAQA
GAGQLLGAKLTDNSAAPLLTAYALRGTDGRTRIALFNKNLDADVEVAISGVASPSGTVLR
LEAPRADDTTDVTFGGAPVGASGSWSPLVQEYVPGHSGQFVLHMRKASGALLEFA
Structure
3VNY ; 3VNZ ; 3VO0 ; 5G0M ; 5G0Q ; 5L77
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PNB-D-xyloside
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003589 Cs_a_deg4 Cs_b_deg2 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003586 Cs_d_deg2 D-glucuronate Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003587 Cs_d_deg2 Cs_a_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003588 Cs_d_deg2 Cs_c_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003588 Cs_d_deg2 Cs_c_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003573 Cs_d_deg3 D-glucuronate Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003574 Cs_d_deg3 Cs_a_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003575 Cs_d_deg3 Cs_c_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003576 Cs_d_deg3 Cs_d_deg4 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
MR003577 Cs_d_deg3 Cs_e_deg4 Hydrolysis - Hydrolysis Chondroitin sulfate [2]
⏷ Show the Full List of 10 MR(s)
References
1 Structural and biochemical characterization of glycoside hydrolase family 79 beta-glucuronidase from Acidobacterium capsulatum. J Biol Chem. 2012 Apr 20;287(17):14069-77.
2 DrugBank(Pharmacology-Metabolism):Chondroitin?sulfate

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