Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN044)
DME Name Ribulose-phosphate 3-epimerase (RPE), Homo sapiens
Gene Name RPE
UniProt ID
RPE_HUMAN
EC Number    EC: 2.7.13.3     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Protein-histidine kinases
EC: 2.7.13.3
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQ
LGQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKVGLAIK
PGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVDGGVGP
DTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSLDR
Structure
3OVP ; 3OVQ ; 3OVR ; 3QC3 ;
Function Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ergocalciferol
 Drug Info Approved Hypoparathyroidism ICD11: 5A50 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003003 Ergocalciferol Beta-ergocalciferol Unclear - Unclear Ergocalciferol [2]
References
1 Vitamin D: Mechanisms of Action and Clinical Applications Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii. doi: 10.1016/j.ecl.2017.09.001.
2 Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.

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