Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN085)
DME Name Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2), Homo sapiens
Gene Name MTHFD2
UniProt ID
MTDC_HUMAN
EC Number    EC: 2.1.2.10     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Hydroxymethyl-, formyl- and related transferases
EC: 2.1.2.10
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
Structure
5TC4 ; 6JIB ; 6JID ; 6KG2 ; 6S4A ; 6S4E ; 6S4F ; 7EHJ ; 7EHM ; 7EHN ; 7EHV ;
Function Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Folic acid
 Drug Info Approved Vitamin deficiency ICD11: 5B55 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001080 Tetrahydrofolic acid 5,10-methylene tetrahydrofolate (THF) Unclear - Unclear Folic acid [1]
References
1 DrugBank(Pharmacology-Metabolism)Folic acid

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