Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN088)
DME Name N-sulphoglucosamine sulphohydrolase (SGSH), Homo sapiens
Gene Name SGSH
UniProt ID
SPHM_HUMAN
EC Number    EC: 3.10.1.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Acting on sulfur-nitrogen bonds
Acting on sulfur-nitrogen bonds
EC: 3.10.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLF
RNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGI
IGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDP
HRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQY
TTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPE
HPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWAT
VFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQP
TGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWV
CAPDGVLEEKLSPQCQPLHNEL
Structure
4MHX ; 4MIV
Function Catalyzes a step in lysosomal heparan sulfate degradation.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Chondroitin sulfate
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003572 Cs_d_deg6 Cs_d_deg3 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003580 Cs_d_deg6 Cs_c_deg5 Hydrolysis - Hydrolysis Chondroitin sulfate [1]
MR003581 Cs_d_deg6 Cs_d_deg6 sulfate Hydrolysis - Hydrolysis Chondroitin sulfate [1]
References
1 DrugBank(Pharmacology-Metabolism):Chondroitin?sulfate

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