Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN095)
DME Name Pentaerythritol tetranitrate reductase (onr), Enterobacter cloacae
Gene Name onr
UniProt ID
P71278_ENTCL
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Enterobacter cloacae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSAEKLFTPLKVGAVTAPNRVFMAPLTRLRSIEPGDIPTPLMGEYYRQRASAGLIISEAT
QISAQAKGYAGAPGLHSPEQIAAWKKITAGVHAEDGRIAVQLWHTGRISHSSIQPGGQAP
VSASALNANTRTSLRDENGNAIRVDTTTPRALELDEIPGIVNDFRQAVANAREAGFDLVE
LHSAHGYLLHQFLSPSSNQRTDQYGGSVENRARLVLEVVDAVCNEWSADRIGIRVSPIGT
FQNVDNGPNEEADALYLIEELAKRGIAYLHMSETDLAGGKPYSEAFRQKVRERFHGVIIG
AGAYTAEKAEDLIGKGLIDAVAFGRDYIANPDLVARLQKKAELNPQRPESFYGGGAEGYT
DYPSL
Structure
1GVO ; 1GVQ ; 1GVR ; 1GVS ; 1H50 ; 1H51 ; 1H60 ; 1H61 ; 1H62 ; 1H63 ; 1VYP ; 1VYR ; 1VYS ; 2ABA ; 2ABB ; 3F03 ; 3KFT ; 3P62 ; 3P67 ; 3P74 ; 3P7Y ; 3P80 ; 3P81 ; 3P82 ; 3P84 ; 3P8I ; 3P8J ; 5LGX ; 5LGZ ; 6GI7 ; 6GI8 ; 6GI9 ; 6GIA
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
NCI-C55743
 Drug Info Phase 3 Foetal growth restriction ICD11: KA20 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003781 NCI-C55743 Pentaerythritol trinitra Reduction - Reduction NCI-C55743 [1]
MR003782 NCI-C55743 Pentaerythritol dinitrate Reduction - Reduction NCI-C55743 [1]
References
1 Degradation of pentaerythritol tetranitrate by Enterobacter cloacae PB2

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