Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN108)
DME Name Malate dehydrogenase (MDH2), Homo sapiens
Gene Name MDH2
UniProt ID
MDHM_HUMAN
EC Number    EC: 1.1.1.37     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.37
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Structure
2DFD ; 4WLE ; 4WLF ; 4WLN ; 4WLO ; 4WLU ; 4WLV
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Oxaloacetate
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003885 L-Malate Oxaloacetate Unclear - Unclear DB-053072 [1]
MR004438 Oxaloacetate L-malate Reduction - Reduction Oxaloacetate [2]
References
1 Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function
2 Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation

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