Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN136)
DME Name Xanthine phosphoribosyltransferase (xpt), Bacillus subtilis
Gene Name xpt
UniProt ID
XPT_BACSU
EC Number    EC: 2.4.2.22     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Pentosyltransferase
EC: 2.4.2.22
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
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Genus: .
Species: Bacillus subtilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKDGITKIVTIESS
GIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQTESQIAVSGTHLSDQDHV
LIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQPGRDELVKLGYRVESLARIQS
LEEGKVSFVQEVHS
Structure
1Y0B ; 2FXV ; 6W1I
Function Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Xanthine
 Drug Info Phase 1 Obstructive sleep apnea ICD11: 7A41 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004024 Xanthine XMP Unclear - Unclear Xanthine [1]
References
1 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism

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