Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN155)
DME Name Inositol polyphosphate 1-phosphatase (INPP1), Homo sapiens
Gene Name INPP1
UniProt ID
INPP_HUMAN
EC Number    EC: 3.1.3.57     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.57
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEV
IKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEA
LARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQ
CVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQCYWGLSYMGTNMHSLQLTISRR
NGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAALSRVCGDRIFGAAGAGYKSLCVVQG
LVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGA
AGVDRWANKGGLIAYRSRKRLETFLSLLVQNLAPAETHT
Function Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
DMI-tetrakisphosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1], [2]
DMI-trisphosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004195 D-myo-inositol 1,3,4-trisphosphate Nositol 1,3-bisphosphate Unclear - Unclear DMI-tetrakisphosphate [1], [2]
MR004202 DMI-trisphosphate Inositol 1,3-bisphosphate Unclear - Unclear DMI-trisphosphate [1], [2]
References
1 The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate
2 Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver

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