Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN163)
DME Name NAD-dependent protein deacetylase HST2 (HST2), Saccharomyces cerevisiae
Gene Name HST2
UniProt ID
HST2_YEAST
EC Number    EC: 2.3.1.286     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.286
Lineage    Species: Saccharomyces cerevisiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Saccharomyces cerevisiae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKL
PYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTL
ERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPA
IVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPR
KVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDN
SKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
Structure
1Q14 ; 1Q17 ; 1Q1A ; 1SZC ; 1SZD ; 2OD2 ; 2OD7 ; 2OD9 ; 2QQF ; 2QQG ; 7F4E ; 7F51
Function NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
D-ribosylnicotinate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012863 NAD+ Nicotinamide (NAM) Unclear - Unclear D-ribosylnicotinate [1]
MR012863 NAD+ Nicotinamide (NAM) Unclear - Unclear D-ribosylnicotinate [1]
References
1 Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

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