Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN220)
DME Name beta-galactosidase (FAEPRAA2165_01145), Faecalibacterium prausnitzii
Gene Name FAEPRAA2165_01145
UniProt ID
C7H4D2_FAEPA
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Faecalibacterium prausnitzii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Faecalibacterium prausnitzii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNRSLLYPRATTTRRLIGLDGMWRFSFDPESKGVEAGWALDLPSSLSMPVPASFCDLFTD
KASREYCGDFWYETSFFVPAEWSGWDIVLRFGSVTHRARVFVNGVEVAQHEGGFLPFDAT
VTNIVRYNQFNKLSVLANNELSETMLPAGTTCTLADGRKIAAPYFDFYNYAGIHRPVWLM
ALPKERVLDYSTRYRLTETGAEIDYTVSTNGPHPVTVELYDGTTRVAESSGTTGTLVVKN
ARLWNVHAAYLYDLVIRIHEGSAVVDEYLDRIGIRTFEIRHGRFLLNGSPVYLRGFGRHE
DADIRGRGLDLPTVKRDFELMKWIGANCFRTSHYPYAEEIYQMADEEGFLIIDEVPAVGF
MQSTANFLAANQGNGRQQGFFEKETTPALLKNHKAALTDMIDRDKNHPSVIAWSLLNEPQ
CTSAGTEEYFKPLFELARRLDPQKRPRTYTVLMTSLPDTSKGQRFADFVSLNRYYGWYVL
GGAGLADAEAAFHHEMDGWAKVLHGRPLIFTEYGTDNLSGAHKLPSVMWSAEYQNEYLEM
THAVFDHYDFVQGELVWNFADFQTTEGILRVDGNKKGIFTRQRQPKDAAYLFRKRWTTLP
VDFKKRKK
Structure
6ED2
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PhIP glucuronide
 Drug Info Investigative Pancreatic cancer ICD11: 2C10 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012941 PhIP glucuronide PhIP Unclear - Unclear PhIP glucuronide [1]
References
1 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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