Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN227)
DME Name Thiol S-methyltransferase TMT1B (TMT1B), Homo sapiens
Gene Name TMT1B
UniProt ID
TMT1B_HUMAN
EC Number    EC: 2.1.1.9     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFS
QIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYE
RFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPY
GSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMG
KAVK
Function Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Ibrutinib
 Drug Info Approved Mantle cell lymphoma ICD11: 2A85 [1]
Penicillamine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012950 S-Methyl-Ibrutinib S-Methyl-Ibrutinib Unclear - Unclear Ibrutinib [1]
References
1 Extrahepatic metabolism of ibrutinib
2 Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril

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