Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN261)
DME Name Acetyl-CoA acetyltransferase (ACAT2), Homo sapiens
Gene Name ACAT2
UniProt ID
THIC_HUMAN
EC Number    EC: 2.3.1.9     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHV
LAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGME
NMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDK
VAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPYFLT
DGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPA
IKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGC
RILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE
Structure
1WL4 ; 1WL5
Function Involved in the biosynthetic pathway of cholesterol.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sodium phenylbutyrate
 Drug Info Approved Muscular atrophy ICD11: 8B61 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR013771 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear - Unclear phenylbutyrate [2]
MR005600 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear - Unclear Sodium phenylbutyrate [1]
References
1 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
2 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

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