Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN783)
DME Name Ornithine transcarbamylase (OTC), Homo sapiens
Gene Name OTC
UniProt ID
OTC_HUMAN
EC Number    EC: 2.1.3.3     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Carboxy- and carbamoyltransferases
EC: 2.1.3.3
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLS
ADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGV
NESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQ
EHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKEN
GTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTF
LHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF
Structure
1C9Y ; 1EP9 ; 1FVO ; 1OTH
Function Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline . The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion .
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008811 P5C Citrulline Unclear - Unclear L-Proline [1]
References
1 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

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