Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000184)
DM Name	(S)-enantiomer of fingolimod-phosphate

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Sphingosine kinase 1 (SPHK1)	DME0484	Fingolimod	Other reaction - Phosphorylation	Fingolimod	[1] , [2]
Sphingosine kinase 1 (SPHK1)	DME0484	Fingolimod hydrochloride	Other reaction - Phosphorylation	Fingolimod hydrochloride	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Fingolimod		DR0696	Approved		Multiple sclerosis

Fingolimod hydrochloride		DR0697	Approved		Multiple sclerosis

References
1	Clinical pharmacokinetics of fingolimod Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000.
2	Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition J Clin Pharmacol. 2009 Feb;49(2):212-8. doi: 10.1177/0091270008329553.

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