Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000192)
DM Name
Fluoro-beta-ureidopropionate
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Dihydropyrimidinase (DPYS) DMEN004
5,6-Dihydro-5-fluorouracil
Hydrolysis - Hydrolysis Floxuridine [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Beta-ureidopropionase (UPB1) DMEN028
Alpha-Fluoro-beta-alanine
Hydrolysis - Hydrolysis Floxuridine [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Floxuridine DR1754 Approved Hepatocellular carcinoma
References
1 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
2 The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, -fluoro--ureidopropionate, -fluoro--alanine using LC-MS J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045.

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