| General Information of Drug Metabolite (DM) (ID: DM000222) |
| DM Name |
Quinoneimine-GSH conjugate
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Glutamate-cysteine ligase catalytic (GCLC)
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DME0485
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| Conjugation - Conjugation |
Lapatinib ditosylate
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Lapatinib ditosylate |
DR0917
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Approved |
Breast cancer |
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| References |
| 1 |
Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib Drug Metab Dispos. 2021 Mar;49(3):233-244. doi: 10.1124/dmd.120.000236.
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