| General Information of Drug Metabolite (DM) (ID: DM000489) |
| DM Name |
27-O-desmethyl temsirolimus
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Oxidation - O-Demethylation |
Temsirolimus
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - O-Demethylation |
Temsirolimus
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Temsirolimus |
DR1548
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Approved |
Renal cell carcinoma |
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| References |
| 1 |
Temsirolimus metabolic pathways revisited Xenobiotica. 2020 Jun;50(6):640-653. doi: 10.1080/00498254.2019.1678793.
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