Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000503)
DM Name
N-Desmethylhydroxyterbinafine
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Cytochrome P450 1A2 (CYP1A2) DME0003
N-Desmethylterbinafine
Oxidation - Hydoxylation Terbinafine hydrochloride [1]
Cytochrome P450 2B6 (CYP2B6) DME0020
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Cytochrome P450 2B6 (CYP2B6) DME0020
N-Desmethylterbinafine
Oxidation - Hydoxylation Terbinafine hydrochloride [1]
Cytochrome P450 2C8 (CYP2C8) DME0018
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Cytochrome P450 2C8 (CYP2C8) DME0018
N-Desmethylterbinafine
Oxidation - Hydoxylation Terbinafine hydrochloride [1]
Cytochrome P450 2C9 (CYP2C9) DME0019
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Cytochrome P450 2C9 (CYP2C9) DME0019
N-Desmethylterbinafine
Oxidation - Hydoxylation Terbinafine hydrochloride [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021
Hydroxyterbinafine
Oxidation - N-Demethylation Terbinafine hydrochloride [1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021
N-Desmethylterbinafine
Oxidation - Hydoxylation Terbinafine hydrochloride [1]
⏷ Show the Full List of DM
Full List of Drug(s) That Produce This DM By Metabolism
Terbinafine hydrochloride DR1557 Approved Pityriasis versicolor
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.
2 A multi-residue chiral liquid chromatography coupled with tandem mass spectrometry method for analysis of antifungal agents and their metabolites in aqueous environmental matrices. Anal Methods. 2021 Jun 14;13(22):2466-2477. doi: 10.1039/d1ay00556a.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.