Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000815)
DM Name	Dexmedetomidine N-glucuronidation

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A4 (UGT1A4)	DME0048	Dexmedetomidine hydrochloride	Conjugation - Glucuronidation	Dexmedetomidine hydrochloride	[1]
UDP-glucuronosyltransferase 2B10 (UGT2B10)	DME0205	Dexmedetomidine hydrochloride	Conjugation - Glucuronidation	Dexmedetomidine hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Dexmedetomidine hydrochloride		DR0472	Approved		Tension headache

References
1	Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients J Pharm Biomed Anal. 2019 Oct 25;175:112777. doi: 10.1016/j.jpba.2019.07.025.

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