Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000828)
DM Name
3-hydroxymorphinan O-glucuronide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [1] , [2]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [3] , [2]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [1] , [2]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [3] , [2]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [1] , [2]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [3] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [1] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
3-hydroxymorphinan
Conjugation - Glucuronidation Dextromethorphan hydrobromide [3] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Dextromethorphan hydrobromide DR0476 Approved Atherosclerosis
References
1 LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):217-25. doi: 10.1016/j.jchromb.2004.09.040.
2 Classics in Chemical Neuroscience: Dextromethorphan (DXM). ACS Chem Neurosci. 2023 Jun 21;14(12):2256-2270. doi: 10.1021/acschemneuro.3c00088.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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