Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000915)
DM Name
6-methoxyethinylestradiol
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Catechol O-methyltransferase (COMT) DME0043
6-hydroxyethinylestradiol
Conjugation - O-Methylation Ethinyl estradiol [1]
Catechol O-methyltransferase (COMT) DME0043
Unclear
Conjugation - O-methylation Ethinylestradiol propanesulfonate [1] , [2]
Monoamine oxidase type A (MAO-A) DME0044
6-hydroxyethinylestradiol
Conjugation - O-Methylation Mestranol [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Sulfotransferase 1A1 (SULT1A1) DME0008
6-methoxyethinylestradiol-sulfate
Conjugation - Sulfation Ethinylestradiol propanesulfonate [1] , [2]
Sulfotransferase 1E1 (SULT1E1) DME0061
6-methoxyethinylestradiol-sulfate
Conjugation - Sulfation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
6-methoxyethinylestradiol-glucuronide
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041
6-methoxyethinylestradiol-glucuronide
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042
6-methoxyethinylestradiol-glucuronide
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
6-methoxyethinylestradiol-glucuronide
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Ethinyl estradiol DR0656 Approved Menopausal disorder
Ethinylestradiol propanesulfonate DR0658 Phase 4 Prostate cancer
Mestranol DR1034 Phase 4 Menorrhagia
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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