Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM001262)
DM Name
Rucaparib M500 metabolite
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
Rucaparib M324 metabolite
Conjugation - Glucuronidation Rucaparib [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Rucaparib DR1449 Approved Ovarian cancer
References
1 Evaluation of absorption, distribution, metabolism, and excretion of [(14)C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors Invest New Drugs. 2020 Jun;38(3):765-775. doi: 10.1007/s10637-019-00815-2.
2 Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment. Cancer Chemother Pharmacol. 2021 Aug;88(2):259-270. doi: 10.1007/s00280-021-04278-2.

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