| General Information of Drug Metabolite (DM) (ID: DM001619) |
| DM Name |
BCV M1
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-Demethylation |
Beclabuvir
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - N-Demethylation |
Beclabuvir
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Beclabuvir |
DR0178
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Phase 4 |
Viral hepatitis |
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| References |
| 1 |
Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir J Hum Genet. 2020 Jan;65(2):143-153. doi: 10.1038/s10038-019-0685-2.
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