Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001998)
DM Name	Ertugliflozin metabolite M2
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Ertugliflozin	Conjugation - Glucuronidation	Ertugliflozin	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Ertugliflozin	Conjugation - Glucuronidation	Ertugliflozin	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Ertugliflozin	Conjugation - Glucuronidation	Ertugliflozin	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Ertugliflozin metabolite M5a	Unclear - Unclear	Ertugliflozin	[2]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Ertugliflozin metabolite M5c	Unclear - Unclear	Ertugliflozin	[2]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	Ertugliflozin metabolite M5a	Unclear - Unclear	Ertugliflozin	[2]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	Ertugliflozin metabolite M5c	Unclear - Unclear	Ertugliflozin	[2]

Full List of Drug(s) That Produce This DM By Metabolism
Ertugliflozin		DR0604	Approved		Diabetes mellitus

References
1	In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171.
2	Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551.

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