Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002034)
DM Name	5-hydroxyfluvastatin

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A1 (CYP1A1)	DME0006	Fluvastatin sodium	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1] , [2]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Fluvastatin sodium	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1] , [2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Fluvastatin sodium	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1] , [2]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Fluvastatin sodium	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Fluvastatin sodium	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Fluvastatin sodium		DR0738	Approved		Hypertriglyceridaemia

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2	Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32.

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