Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002250)
DM Name	Nintedanib metabolite M13
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Nintedanib esylate	Unclear - Unclear	Nintedanib esylate	[1]
Cytochrome P450 2E1 (CYP2E1)	DME0013	Nintedanib esylate	Unclear - Unclear	Nintedanib esylate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Nintedanib esylate	Unclear - Unclear	Nintedanib esylate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Nintedanib esylate		DR1163	Approved		Idiopathic pulmonary fibrosis

References
1	Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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