Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002458)
DM Name	Carboxylic acid

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Alcohol dehydrogenase class-I alpha (ADH1A)	DME0127	PEG	Unclear - Unclear	Certolizumab pegol	[1]
Cytochrome P450 124A1 (cyp124A1)	DMEN359	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]
Cytochrome P450 124A1 (cyp124A1)	DMEN360	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]
Cytochrome P450 125A1 (cyp125A1)	DMEN357	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]
Cytochrome P450 142A1 (cyp142A1)	DMEN358	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]
Steroid C26-monooxygenase (cyp125A1)	DMEN355	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]
Steroid C26-monooxygenase (cyp142A1)	DMEN356	27-hydroxycholesterol	Unclear - Unclear	ANW-32821	[2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Certolizumab pegol		DR0291	Approved		Crohn disease

ANW-32821		DR2314	Phase 2		Cone rod dystrophy

References
1	LABEL:CIMZIA- certolizumab pegol kit CIMZIA- certolizumab pegol injection
2	Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25.
3	Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.

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