| General Information of Drug Metabolite (DM) (ID: DM002564) |
| DM Name |
Imrecoxib metabolite M1
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Unclear - Unclear |
Imrecoxib
|
[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
Imrecoxib
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[1] , [2] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
|
DME0009
|
| Unclear - Unclear |
Imrecoxib
|
[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Unclear - Unclear |
Imrecoxib
|
[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Imrecoxib |
DR1914
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Phase 4 |
Osteoarthritis |
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| References |
| 1 |
Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate Drug Metab Dispos. 2018 Sep;46(9):1320-1328. doi: 10.1124/dmd.118.081182.
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| 2 |
Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects. Drug Des Devel Ther. 2022 Nov 8;16:3865-3876. doi: 10.2147/DDDT.S387508.
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