| General Information of Drug Metabolite (DM) (ID: DM003321) |
| DM Name |
LY-2484595 Metabolite M4
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
LY-450139
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| LY-2484595 |
DR1878
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Phase 3 |
Myocardial infarction |
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| LY-450139 |
DR1888
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Phase 3 |
Alzheimer disease |
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| References |
| 1 |
Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.
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