| General Information of Drug Metabolite (DM) (ID: DM003465) |
| DM Name |
H3B-6527 Metabolite M807
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Gamma-glutamyltranspeptidase 5 (GGT5)
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DME0432
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| Hydrolysis - Hydrolysis |
H3B-6527
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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amino dipeptidases (AMD)
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DMEN123
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| Unclear - Unclear |
H3B-6527
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| H3B-6527 |
DR1800
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Phase 1 |
Hepatocellular carcinoma |
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| References |
| 1 |
Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study. Xenobiotica. 2020 Apr;50(4):458-467.
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