| General Information of Drug Metabolite (DM) (ID: DM004585) |
| DM Name |
2-(o-carboxybenzamido)glutaric acid
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[1] |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[2] |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[2] |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[2] |
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Nonenzymatical (Non-ME)
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DMEN081
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| Conjugation - Amide Hydrolyation |
Thalidomide
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[2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Thalidomide |
DR1572
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Approved |
Breast cancer |
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| References |
| 1 |
Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
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| 2 |
Thalidomide metabolism and hydrolysis: mechanisms and implications
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