Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004889)
DM Name	5'-hydroxytegafur

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2A6 (CYP2A6)	DME0005	Tegafur	Oxidation - 5-hydroxylation	Tegafur	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Fluorouracil	Other reaction - Degradation	Tegafur	[1] , [2]
Cytochrome P450 2A6 (CYP2A6)	DME0005	Fluorouracil	Other reaction - Degradation	Tegafur	[1] , [2]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Fluorouracil	Other reaction - Degradation	Tegafur	[1] , [2]
Cytochrome P450 2E1 (CYP2E1)	DME0013	Fluorouracil	Other reaction - Degradation	Tegafur	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Fluorouracil	Other reaction - Degradation	Tegafur	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Tegafur		DR1539	Phase 4		Colon cancer

References
1	Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2	Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.

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