Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM005058)
DM Name	Finerenone M14 Metabolite
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Finerenone	Unclear - Unclear	Finerenone	[1] , [2] , [3]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Finerenone	Unclear - Unclear	Finerenone	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Finerenone		DR3519	Phase 3		Diabetic nephropathy

References
1	Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
2	Aldosterone and Mineralocorticoid Receptor Signaling as Determinants of Cardiovascular and Renal Injury: From Hans Selye to the Present
3	Results From Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.