| General Information of Drug Metabolite (DM) (ID: DM005951) |
| DM Name |
Hydrolyzed triptolide
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydrolyzationn |
PG-490
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[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - Hydrolyzationn |
PG-490
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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N-acetyltransferases (NATs)
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DMEN325
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| Conjugation - Conjugation |
PG-490
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| PG-490 |
DR1904
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Phase 3 |
Diabetes mellitus |
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| References |
| 1 |
Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.
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