Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006440)
DM Name	beta-hydroxy acid of lovastatin
PubChem CID	386477161

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Serum paraoxonase/lactonase 3 (PON3)	DME0170	Lovastatin	Hydrolysis - Hydrolysis	Lovastatin	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Carboxylesterase (CES)	DMEN121	3''-Hydroxylovastatin	Unclear - Unclear	Lovastatin	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
Cytochrome P450 2C9 (CYP2C9)	DME0019	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
Cytochrome P450 2D6 (CYP2D6)	DME0009	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
Cytochrome P450 3A4 (CYP3A4)	DME0001	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
Cytochrome P450 3A5 (CYP3A5)	DME0012	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	6'-beta-Hydroxylovastatin	Oxidation - Hydrolyzationn	Lovastatin	[3]

Full List of Drug(s) That Produce This DM By Metabolism
Lovastatin		DR0986	Approved		Hypertriglyceridaemia

References
1	Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2	Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
3	Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.

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