Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006619)
DM Name	4-methoxyethinylestradiol-sulfate

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Sulfotransferase 1A1 (SULT1A1)	DME0008	4-methoxyethinylestradiol	Conjugation - Sulfation	Ethinylestradiol propanesulfonate	[1] , [2]
Sulfotransferase 1E1 (SULT1E1)	DME0061	4-methoxyethinylestradiol	Conjugation - Sulfation	Ethinylestradiol propanesulfonate	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Ethinylestradiol propanesulfonate		DR0658	Phase 4		Prostate cancer

References
1	Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2	Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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