| General Information of Drug Metabolite (DM) (ID: DM006862) |
| DM Name |
SN38
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
EZN-2208
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| EZN-2208 |
DR1826
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Phase 2 |
Colorectal cancer |
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| References |
| 1 |
Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer. Cancer Chemother Pharmacol. 2013 Jun;71(6):1499-506.
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