| General Information of Drug Metabolite (DM) (ID: DM006886) |
| DM Name |
SN-38G
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Conjugation - Glucuronidation |
SN-38
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[1] , [2] |
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UDP-glucuronosyltransferase 1A7 (UGT1A7)
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DME0065
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| Conjugation - Glucuronidation |
SN-38
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[1] , [2] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - Glucuronidation |
SN-38
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| SN-38 |
DR0024
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Phase 2 |
Colorectal cancer |
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| References |
| 1 |
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
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| 2 |
Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics
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