| General Information of Drug Metabolite (DM) (ID: DM017022) |
| DM Name |
Loxoprofen trans-OH metabolite
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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NADPH-dependent carbonyl reductase 1 (CBR1)
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DME0067
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| Reduction - Reduction |
Loxoprofen gel
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[1] , [2] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 2B7 (UGT2B7)
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DME0040
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| Unclear - Unclear |
Loxoprofen gel
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Loxoprofen gel |
DR5328
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Approved |
Inflammation |
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| References |
| 1 |
Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat
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| 2 |
Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112.
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